Learning induces transient upregulation of brevican in the auditory cortex during consolidation of long-term memories.

It is a daily challenge for our brains to establish new memories via learning while providing stable storage of remote memories. The capacity to learn throughout life and at the same time guarantee lifelong storage and remote recall of established memories is a daily challenge. Emerging evidence suggests an important function of the extracellular matrix (ECM), a conglomerate of secreted proteins and polysaccharides in the adult vertebrate brain.  Our data may provide novel therapeutic implications for several neuropsychiatric diseases involving dysregulation of the ECM.

https://www.jneurosci.org/content/early/2019/06/19/JNEUROSCI.2499-18.2019