Glutamine plus glutamate (Glx), as well as N-acetylaspartate compounds, (NAAc), a marker of neuronal viability, are quantified with proton magnetic resonance spectroscopy (H-MRS) and have been reported altered in psychotic disorders. However, few studies have compared these neurometabolites in bipolar disorder and schizophrenia. Chronically-treated bipolar-I have increased Glx and reduced NAAc, suggestive of neuronal dysfunction. The NAAc reductions are more severe in bipolar-I than in schizophrenia patients.
https://www.sciencedirect.com/science/article/abs/pii/S0165032718312874
El trastorno bipolar-I tratado crónicamente ha aumentado Glx y reducido NAAc, lo que sugiere disfunción neuronal. Las reducciones de NAAc son más graves en pacientes con bipolar-I que en pacientes con esquizofrenia.
