Maternal and early postnatal immune activation produce sex-specific effects on autism-like behaviors and neuroimmune function in mice.

We examined the effects of early-life immune system activation (EIA)—comprising regimens of prenatal, early postnatal, or combined (“two-hit”) immune activation—on the core behavioral features of ASD (decreased social interaction, increased repetitive behavior, and aberrant communication) in mice.  There is increasing evidence that the immune system is involved in neuropsychiatric illnesses. There are higher rates of… Continuar lendo Maternal and early postnatal immune activation produce sex-specific effects on autism-like behaviors and neuroimmune function in mice.

“We Have to Stop Trivializing ADHD”.

“The group with ADHD is at highest risk for having additional mental health problems,” says Barbaresi, who directs the Developmental Medicine Center at Boston Children’s Hospital and is an associate professor of pediatrics at Harvard Medical School. “We have to stop trivializing ADHD as just another childhood behavior problem. The nature and duration of this study show… Continuar lendo “We Have to Stop Trivializing ADHD”.

Proton magnetic resonance spectroscopic imaging of gray and white matter in bipolar-I and schizophrenia.

Glutamine plus glutamate (Glx), as well as N-acetylaspartate compounds, (NAAc), a marker of neuronal viability, are quantified with proton magnetic resonance spectroscopy (H-MRS) and have been reported altered in psychotic disorders. However, few studies have compared these neurometabolites in bipolar disorder and schizophrenia. Chronically-treated bipolar-I have increased Glx and reduced NAAc, suggestive of neuronal dysfunction. The… Continuar lendo Proton magnetic resonance spectroscopic imaging of gray and white matter in bipolar-I and schizophrenia.