“A huge step forward in identifying how the brain makes and stores memories. Our research demonstrates that Netrin is critical for changes in the strength of connections between brain cells, and offers a new, previously undiscovered target for diseases that affect memory function.” https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31458-X https://reliawire.com/neuronal-netrin-1/
Enormous genomic analysis yields tantalizing insights into mechanisms behind conditions such as schizophrenia and bipolar disorder. The PsychENCODE Consortium, which was founded by the US National Institutes of Health in 2015, aims to join the dots between these genetic associations and actual changes in gene function, by taking samples of brain tissue from thousands of cadavers… Continuar lendo Huge brain study uncovers ‘buried’ genetic networks linked to mental illness.
The brain is responsible for cognition, behavior, and much of what makes us uniquely human. The development of the brain is a highly complex process, and this process is reliant on precise regulation of molecular and cellular events grounded in the spatiotemporal regulation of the transcriptome. Disruption of this regulation can lead to neuropsychiatric disorders.… Continuar lendo Integrative functional genomic analysis of human brain development and neuropsychiatric risks.