Losing sleep over Alzheimer’s disease In patients with Alzheimer’s disease (AD), amyloid-β (Aβ) plaques and tau protein tangles accumulate in the brain long before the appearance of clinical symptoms. Early intervention is critical for slowing neurodegeneration and disease progression. Therefore, reliable markers of early AD are needed. Lucey et al. analyzed sleep patterns in aging cognitively normal… Continuar lendo Reduced non–rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease.