Glutamine plus glutamate (Glx), as well as N-acetylaspartate compounds, (NAAc), a marker of neuronal viability, are quantified with proton magnetic resonance spectroscopy (H-MRS) and have been reported altered in psychotic disorders. However, few studies have compared these neurometabolites in bipolar disorder and schizophrenia. Chronically-treated bipolar-I have increased Glx and reduced NAAc, suggestive of neuronal dysfunction. The… Continuar lendo Proton magnetic resonance spectroscopic imaging of gray and white matter in bipolar-I and schizophrenia.