The exome sequences of approximately 8,000 children with autism spectrum disorder (ASD) and/or attention deficit hyperactivity disorder (ADHD) and 5,000 controls were analyzed, finding that individuals with ASD and individuals with ADHD had a similar burden of rare protein-truncating variants in evolutionarily constrained genes, both significantly higher than controls. This motivated a combined analysis across ASD and ADHD, identifying microtubule-associated protein 1A (MAP1A) as a new exome-wide significant gene conferring risk for childhood psychiatric disorders.
https://www.nature.com/articles/s41593-019-0527-8
“The very fact that mutations are found to the same extent and in the same genes in children with autism and in children with ADHD, points towards the same biological mechanisms being involved,” said Anders Børglum, PhD, who is a professor at Aarhus University and one of the leading researchers behind the study.
In Denmark, approximately one percent of schoolchildren have autism and two to three percent are diagnosed with ADHD. Autism and ADHD are different developmental disorders, but they can have certain common symptoms.
https://www.genengnews.com/news/autism-and-adhd-share-a-common-genetic-burden/
Investigadores de la Universidad de Aarhus (Dinamarca) han descubierto, en un estudio publicado en la revista ‘Nature Neuroscience’, que el autismo y el trastorno por déficit de atención e hiperactividad (TDAH) comparten cambios en los mismos genes.
“El hecho de que las mutaciones se encuentren en la misma medida y en los mismos genes en niños con autismo y en niños con TDAH, apunta hacia los mismos mecanismos biológicos involucrados”, han comentado los investigadores.
