Mediation of the influence of childhood maltreatment on depression relapse by cortical structure.
They link childhood abuse with changes in the brain and subsequent depression.
Early life stress has a detrimental effect on brain structure, which increases the risk of unfavourable disease courses in major depression. Clinical and translational research should explore the role of childhood maltreatment as causing a potential clinically and biologically distinct subtype of major depressive disorder.
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(19)30044-6/fulltext
