Genetic factors are strongly implicated in the susceptibility to develop externalizing syndromes such as attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, and substance use disorder (SUD). Variants in the ADGRL3 (LPHN3) gene predispose to ADHD and predict ADHD severity, disruptive behaviors comorbidity, long-term outcome, and response to treatment.
Our results support a possible functional role for ADGRL3 in modulating drug seeking behavior. Regardless of the type of abused substance, longitudinal studies generally find that the onset of ADHD precedes that of SUD – substance use disorder, suggesting that the psychopathology of ADHD is not secondary to SUD in most patients79. Accordingly, it is reasonable to consider that timely diagnosis and treatment of ADHD with stimulant medication may reduce the occurrence and/or severity of SUD.
https://www.nature.com/articles/s41398-019-0396-7
Algunas variaciones en el gen LPHN3, relacionado con el trastorno por déficit de atención/hiperactividad (TDAH) en niños y adultos, podrían favorecer la predisposición a consumir tabaco, alcohol, cannabis y otras sustancias adictivas.
